- Stuart Greer (3 movies)
- Stuart Wilson (3 movies)
- Sunny Sandler (3 movies)
- Suzy Nakamura (3 movies)
- Sylvester McCoy (3 movies)
- Sally Field (4 movies)
- Sally Phillips (4 movies)
- Sam Jaeger (4 movies)
- Sam Riley (4 movies)
- Samantha Bond (4 movies)
- Sami Gayle (4 movies)
- Sanaa Lathan (4 movies)
- Sandra Ellis Lafferty (4 movies)
- Sarah Paulson (4 movies)
- Sasha Barrese (4 movies)
- Saul Rubinek (4 movies)
- Sayed Badreya (4 movies)
- Scott Caan (4 movies)
- Scott Porter (4 movies)
- Seamus Davey-Fitzpatrick (4 movies)
- Sean Biggerstaff (4 movies)
- Sean Bridgers (4 movies)
- Sean Pertwee (4 movies)
- Sebastian Hülk (4 movies)
- Seth Adkins (4 movies)
- Seth Green (4 movies)
- Sharon Stone (4 movies)
- Shawn Ashmore (4 movies)
- Shawn Hatosy (4 movies)
- Shefali Chowdhury (4 movies)
- Sherri Shepherd (4 movies)
- Shun Sugata (4 movies)
- Sissy Spacek (4 movies)
- Socratis Otto (4 movies)
- Sope Aluko (4 movies)
- Spencer Locke (4 movies)
- Spencer Wilding (4 movies)
- Spike Jonze (4 movies)
- Stephanie Szostak (4 movies)
- Stephen Bishop (4 movies)
- Stephen Colbert (4 movies)
- Stephen R. Hart (4 movies)
- Stephen Rea (4 movies)
- Sterling Jerins (4 movies)
- Steve Eastin (4 movies)
- Steve Witting (4 movies)
- Steven Mackintosh (4 movies)
- Sugar Lyn Beard (4 movies)
- Sullivan Stapleton (4 movies)
- Saïd Taghmaoui (5 movies)