- Selma Blair (6 movies)
- Selom Awadzi (1 movie)
- Selva Rasalingam (1 movie)
- Semion Sudarikov (1 movie)
- Senkichi Ômura (1 movie)
- Senyo Amoaku (1 movie)
- Septimus Caton (2 movies)
- Ser'Darius Blain (1 movie)
- Serafeim Radis (1 movie)
- Serban Celea (1 movie)
- Seregon O'Dassey (1 movie)
- Serena Akane Chi (1 movie)
- Serena Brabazon (1 movie)
- Serena Gordon (1 movie)
- Serena Scott Thomas (1 movie)
- Serena Williams (1 movie)
- Serge Bagdassarian (1 movie)
- Serge Hazanavicius (1 movie)
- Serge Houde (3 movies)
- Serge Merlin (1 movie)
- Sergei Ashurov (1 movie)
- Sergej Trifunović (2 movies)
- Sergey Brin (1 movie)
- Sergey Ovchinnikov (1 movie)
- Sergey Trofimov (1 movie)
- Sergi López (1 movie)
- Sergio Calderón (1 movie)
- Sergio Di Zio (2 movies)
- Sergio Kato (2 movies)
- Sergio Montalvo (1 movie)
- Sergio Peris-Mencheta (1 movie)
- Sergio Torrado (1 movie)
- Serinda Swan (2 movies)
- Seth Adkins (4 movies)
- Seth Ayott (1 movie)
- Seth Barrish (2 movies)
- Seth Gabel (1 movie)
- Seth Gilliam (1 movie)
- Seth Ginsberg (1 movie)
- Seth Green (4 movies)
- Seth Howard (1 movie)
- Seth MacFarlane (7 movies)
- Seth Meriwether (1 movie)
- Seth Meyers (3 movies)
- Seth Rogen (25 movies)
- Seth Zielicke (1 movie)
- Seu Jorge (1 movie)
- Severn Darden (2 movies)
- Severyn K. Brodziak (1 movie)
- Sewell Whitney (1 movie)