- Melissa McCarthy (9 movies)
- Melissa McMeekin (2 movies)
- Melissa Molinaro (1 movie)
- Melissa Ordway (3 movies)
- Melissa Paulo (2 movies)
- Melissa Rae Mahon (1 movie)
- Melissa Rauch (2 movies)
- Melissa Roxburgh (1 movie)
- Melissa Sagemiller (2 movies)
- Melissa Steinman (1 movie)
- Melissa Stribling (1 movie)
- Melissa Sturm (3 movies)
- Melissa Tang (1 movie)
- Melita Jurišić (1 movie)
- Mella Carron (1 movie)
- Mellan Mitchell (1 movie)
- Mellany Gandara (1 movie)
- Mélodie Simard (1 movie)
- Melody Weintraub (1 movie)
- Melody Zara (1 movie)
- Melonie Diaz (3 movies)
- Melora Hardin (2 movies)
- Melora Walters (1 movie)
- Melvin Brown (1 movie)
- Mena Suvari (3 movies)
- Menyone DeVeaux (1 movie)
- Merab Ninidze (1 movie)
- Mercedes Leggett (2 movies)
- Mercedes McCambridge (1 movie)
- Mercedes Ngoh (1 movie)
- Meredith Braun (1 movie)
- Meredith Droeger (1 movie)
- Meredith McGeachie (1 movie)
- Meredith Salenger (1 movie)
- Meredith Scott Lynn (1 movie)
- Meredith Travers (1 movie)
- Meredith Vieira (2 movies)
- Meret Becker (1 movie)
- Merik Tadros (1 movie)
- Merle Dandridge (1 movie)
- Merle Wiebensohn (1 movie)
- Merrik Foune (1 movie)
- Merrilee McCommas (1 movie)
- Merrily Cretton (1 movie)
- Merritt Patterson (1 movie)
- Merritt Wever (2 movies)
- Meryl Streep (16 movies)
- Meryl Williams (1 movie)
- Meta Golding (2 movies)
- Method Man (3 movies)